幽门螺杆菌感染对慢性乙型肝炎患者治疗的影响研究

Effect of Helicobacter pylori infection on treatment of patients with chronic hepatitis B

目的观察慢性乙型肝炎患者幽门螺杆菌(Hp)的感染状况,并探讨其临床意义。方法选取2009年2月-2012年11月医院门诊或住院部收治的慢性乙型肝炎患者共52例,患者入院后通过酶联免疫吸附试验对血清乙型肝炎病毒(HBV)进行检测,同时采用聚合酶链反应进行HBV-DNA测定确定HBV感染,其中HBV-DNA阳性组为37例,HBV-DNA阴性组为15例;幽门螺杆菌检测中采用血清学、14 C呼气试验以及组织学染色、细菌培养等方法进行。结果慢性乙型肝炎患者Hp感染为34例,感染率为65.4%,其中HBV-DNA检测阳性37例患者中Hp感染28例,感染率为75.6%,HBV-DNA检测阴性的15例患者中Hp感染6例,感染率为40.0%,对比结果差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者临床治疗过程中具有较高的Hp感染率,同时也是此类患者出现消化性溃疡的重要原因,加强对其的检测分析对临床治疗和预后具有积极指导意义。

OBJECTIVE To observe the incidence of Helicobacter pylori infections in the patients with chronic hepatitis B and explore its clinical significance. METHODS A total of 52 patients with chronic hepatitis B who were treated in the outpatient department or inpatient department from Feb 2009 to Nov 2012 were enrolled in the study. After the admission to hospital, the serum hepatitis 13 virus （HBV） was detected by using enzyme-linked immunosorbent assay, the HBV-DNA was determined with the use of polymerase-chain-reaction so as to confirm the HBV infection; the positive HBV-DNA positive group included 37 cases, the negative HBV-DNA positive group 15 cases; the serological test, carbon 14 breath test, histological staining, and bacterial culture were performed for the detection of H. pylori. RESULTS The H. pylori infection occurred in 34 chronic hepatitis B patients with the infection rate of 65. 4%, including 28 of 37 （75. 6%） patients with HBV-DNA tested positive and 6 of 15 （40.0%） of patients with HBV-DNA tested negative, and there was statistically difference （P〈0. 05）, CONCLUSION The incidence of H. pylori infection is high in the patients with chronic hepatitis B during the clinical treatment, which is a leading cause of peptic ulcer. It is of great significance to the clinical treatment and prognosis to strengthen the detection of H. pylori.