改性纤维素微球的制备及其药物缓释性能研究

Synthesis and Release Property of Modified Cellulose Microspheres

将微晶纤维素(MCC)溶于1-烯丙基-3-甲基氯代咪唑(AmimCl)离子液体中,使用4-二甲氨基吡啶(DMAP)作为催化剂,采用开环聚合的方法,成功合成了纤维素接枝L-聚乳酸(Cellulose-g-PLLA),并采用乳化-溶剂挥发法成功制备了纤维素微球。通过核磁共振(HNMR)、透射电子显微镜(TEM)等对聚合物进行表征。对微球的降解性、缓释性及缓释动力学进行了探讨。结果表明,Cellulose-g-PLLA微球具有作为缓释药物载体的能力。

A cellulose-based degradable material cellulosegraft-poly（L-lactide） was successfully attained via ring-opening polymerization （ROP） in an ionic liquid. The microsphere was prepared by emulsification-solvent evaporation method. The structure and morphology of the polymer were characterized by nuclear magnetic resonance （NMB） and transmission electron microscope （TEM）. The degradation of cellulose-g- PLLA demonstrate significantly different characteristics, which dominated the drug-release mechanism of the cellulose-g- PLLA microspheres. It showed that the drug-release rate increased with the decrease of graft degree of the cellulose-g- PLLA. Consequently, the cellulose-g-PLLA microspheres might be used as a potential polymer for the controlled release of drugs.