丹七片对心肌缺血小型猪心脏结构与功能的影响

Effect of Danqi Tablet on Myocardial Structure and Function of Chronic Myocardial Ischemia Swines

目的:探讨丹七片对慢性心肌缺血小型猪心脏结构与功能的影响。方法:缩窄环法制备小型猪心肌缺血模型,给予丹七片9 g/只·d(临床等效剂量)4周。超声心动图、大体病理观察、心肌组织石蜡切片HE和Masson染色分析心脏结构与功能的变化。结果:丹七片组动物室间隔收缩末厚度、心内膜下白色瘢痕组织的数量及大小、绿染胶原沉积面积等方面均较模型组显著改善。结论:丹七片虽不能逆转整体心功能,但具有一定的减小缺血范围、改善慢性心肌缺血与心室重构的作用。

Objective ： To explore the effect of Danqi Tablet on myocardial ischemia. Methods ： Myocardial ischemia was induced by a constrictor on the left coronary artery. After treated by Danqi Tablet with a dose of 9 g per day for 4 weeks, echocardiography was performed. And then changes of both general heart and myocardial slices stained by HE or Masson were observed. Results ： Increased end - systolic thickness of ventricular interval was detected by echocardiography while decreased number and area of white scares under endocardium as well as the collagen deposit area in Masson stained slices was found in the Danqi Tablet treated animals. Conclusions ： Danqi Tablet may reduce the ischemia area and improve myocardial remodeling in chronic myocardial ischemia animals.