中药穴位注射联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎的临床研究

Clinical Research of Chinese Drug Acupoint Injection Combined PEG-IFN a-2a to Treat Chronic Hepatitis b

目的:探讨中药穴位注射联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎的疗效。方法:使用柴胡注射液、黄芪注射液、丹参注射液分别注射曲池、足三里、三阴交穴位,联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎62例,随机分组后,观察穴位组与对照组两组的HBV-DNA阴转率、肝功能复常率以及Zung抑郁量表评分。结果:治疗后1周、24周、48周的穴位组SDS评分均明显比对照组低,且在治疗的第1周两组评分分别是(44.1±6.9)和(63.6±3.9),P<0.05,存在显著性差异;穴位组的肝功复常率及DNA阴转率高于单纯使用干扰素治疗的对照组,但差异无统计学意义。结论:中药穴位注射联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎,可减少干扰素的不良反应,且疗效优于对照组。

Objective：To investigate the clinical efficacy of Chinese drug acupoint injection combined PEG -IFN a- 2a to treat chronic hepatitis b. Methods：Use Radix Bupleuri injection, Astragalus injection and Solvia miltiorrhiza injection to point inject quchi, Zusanli and sanyijiao acupoints respectively, combine the treatmenl of using interferon to treat 62 patients of chronic hepatitis b, according therapy was given to randomized groups,we observe the negative HBV - DNA, nor-malization rate of liver function, Zung depression scale scores of the group of acupointure compare with the control group. Result：After 1 week ,24 weeks and 48 weeks later,SDS score of acupuncture group was obviously lower than the control group. After 1 week of treatment, SDS score of acupuncture group and control group was （44.1 ± 6.9） and （63.6± 3.9） respectively ,with statistically significant diference （ P 〈 0.05 ）. The rate of negative HBV - DNA, normalization rate of liv- er function of acupuncture group were highter than that of the control group,but without statistically significant diference. Conclusion ：The therapy of traditional Chinese medicine acupuncture point injection combined PEG -IFN a -2a to treat chronic hepatitis b., has less adverse reaction and better clinical effect.