中药保妇康与干扰素联合治疗宫颈糜烂合并HPV感染的临床观察

Clinical Observation of Baofukang Combined with Interferon in the Treatment of Cervical Erosion Complicated with HPV Infection

目的:探讨保妇康栓与干扰素联合应用治疗宫颈糜烂合并HPV感染的临床效果。方法:选取2010年6月—2013年6月收治的320例宫颈糜烂合并HPV感染的患者,分为保妇康栓组(110例)、干扰素组(100例)及联合用药组(110例),比较三组治疗前后的HPV-DNA负荷量、HPV的转阴率及宫颈糜烂治愈率。结果:治疗后,3组患者的HPV-DNA负荷量较治疗前均明显下降,差异均具有统计学意义(均P<0.05);联合用药组的HPV转阴率达92.8%,明显高于单药组的59.1%和干扰素组的61.0%,差异均有统计学意义(均P<0.05);联合用药组的宫颈糜烂治愈率为84.5%,明显高于其他两组相比,差异均有统计学意义(均P<0.05)。结论:保妇康栓联合干扰素能有效治疗宫颈糜烂合并HPV感染,预防宫颈癌的发生。

Objective ： To discuss the clinical effect of combined application of Baofukang suppositories and interferon in the treatment of cervical erosion complicated with HPV infection. Methods ： 320 patients with cervical erosion complicat- ed with HPV infection enrolled in our hospita from June 2010 to June 2013 1, were divided into Baofukang suppository group （ 110 cases ）, interferon group （ 100 cases ） and combination group （ 110 cases）, HPV - DNA load, negative rate of HPV before and after treatment and cure rate of cervical erosion in three groups were compared. Results ： After treatment, HPV - DNA load of patients in three groups decreased, and the differences were statistically significant （ P 〈 0.05 ） ; The negative rate of HPV in the combined group was 92.8%, significantly higher than 59.1% in the single drug group and 61% in he interferon group, and the differences were statistically significant （P 〈 0.05 ） ;The cure rate of cervical erosion in the combination group, was 84.5 % , significantly higher than that in other two groups, and the difference had statistical significance （ P 〈 0. 05 ）. Conclusion ： Baofnkang suppository combined with interferon is effective in the treatment of cervical erosion complicated with HPV infection, and in prevention of the cervical cancer.