阿司匹林抵抗与脑卒中防治的现状

Status review of aspirin resistance and stroke prevention

阿司匹林目前是预防缺血性脑卒中复发的最有效的抗血小板聚集药物,但很多患者长期规律口服治疗剂量的阿司匹林仍不能有效地阻止血栓性疾病的复发,即存在"阿司匹林抵抗现象"。其发生机制可能与药物的剂量、患者依从性、药物的相互作用、疾病的影响及基因多态性等有关。临床医师应明确阿司匹林抵抗的产生机制,并在临床上采取合适的措施来减少阿司匹林抵抗,从而取得理想的缺血性卒中预防及治疗效果。

Aspirin is one of the well-known drugs of prevention from cerebral ischemic stroke ,with its effective role in exhibiting platelet aggregation .However ,recurrent thrombotic ischemic event still occur in those taking proper dose of aspirin regularly , which called the concept of “aspirin resistance （ AR ）”.The possible mechanisms of AR include aspirin dosage , poor patients′compliance , drug interaction , diseases influence and genetic polymorphisms of relative genes .Therefore, clinical doctors should confirm the mechanisms of AR and the proper counter-measures to reduce even to prevent AR to get the great preventive and therapeutic efficacy .