羟乙基淀粉治疗小儿肾病综合征重度水肿的疗效

Clinical Effect of Hydroxyethyl Starch for the Treatment of Severe Edema of Pediatric Nephrotic Syndrome

目的探讨分析羟乙基淀粉治疗小儿肾病综合征重度水肿的疗效及其安全性。方法将该院近5年收治的46例肾病综合征重度水肿患儿,采用随机分组方法分为试验组和对照组,试验组给予静脉滴注羟乙基淀粉加静脉注射呋塞米,对照组给予静脉滴注低分子右旋糖酐和静脉注射呋塞米。两组患者均治疗3 d,观察治疗过程中不良反应的发生情况和治疗效果,包括尿量、腹围、体重变化情况。结果治疗3 d后,试验组尿量、腹围、体重改变情况明显优于对照组,差异有统计学意义;治疗过程中试验组不良反应发生率为4.3%,对照组为30.4%,两组比较,差异有统计学意义(P<0.05)。结论羟乙基淀粉治疗肾病综合征水肿疗效理想,不良反应少,安全性较好,值得推广。

Objective To discuss and analyze the clinical effect and safety of hydroxyethyl starch for the treatment of severe edema of pediatric nephrotic syndrome. Methods 46 cases of severe edema of pediatric nephrotic syndrome admitted in our hospital in recent 5 years were randomly divided into experiment group and control group. Experiment group was given hydroxyethyl starch （i. v. drip） combined furosemide （i.v.） while control group was given low molecular dextran （i.v. drip） combined furosemide （i.v.）. The treatment course of both groups was 3 days. The occurrence of adverse effects and clinical effects including the changes of urine volume, abdominal girth and weight were observed during the treatment course. Results After 3 days of treatment, the changes of urine volume, abdominal girth and weight of experiment group were obviously better than those of control group, the difference was statistically significant; the incidence of adverse reactions of experiment group was 4.3% and that of control group was 30.4%, the difference was statistically significant, P〈0.05. Conclusion Hydroxyethyl starch for the treatment of edema of pediatric nephrotic syndrome has ideal clinical effect, few adverse reactions and high safety, so it＆#39;s worth of being popularized.