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瑞舒伐他汀对于心肌肥厚大鼠的作用及机制研究

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摘要 目的分析瑞舒伐他汀对于心肌肥厚大鼠的疗效以及相关机制。方法随机将心肌肥厚大鼠分为两组,分别注射瑞舒伐他汀和生理盐水,对两组大鼠的大鼠体重、左心室重量、右心室重量、心脏的重量、血清MMP-2,MMP-3和MMP-9含量进行观察。结果观察组的大鼠体重、左心室重量、右心室重量和心脏的重量均低于对照组的患者;观察组的MMP-2,MMP-3和MMP-9含量均低于对照组的患者(P<0.05)。结论瑞舒伐他汀可以通过抑制MMP活性逆转心肌肥厚。
出处 《中外医疗》 2014年第17期127-128,共2页 China & Foreign Medical Treatment
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