清创及生物羊膜移植联合药物治疗真菌性角膜炎

Debridement and biological amniotic membrane transplantation combined with antifungal drugs for fungal keratitis

目的 探讨角膜清创联合生物羊膜移植并术后抗真菌药物治疗真菌性角膜炎的效果.方法 真菌性角膜炎39例（39眼）,采用角膜清创联合生物羊膜移植术,术后结膜下注射抗真菌药物及局部抗真菌滴眼液滴眼.随访3～6月,裂隙灯显微镜观察生物羊膜愈合情况、角膜溃疡情况、视力提高情况.结果 36例角膜溃疡愈合,3例因羊膜脱落,再次行生物羊膜移植术,术后继续局部治疗,溃疡愈合良好.结论 角膜清创联合生物羊膜移植并术后抗真菌药物结膜下注射是一种行之有效的治疗真菌性角膜炎方法.

Objective To evaluate the efficacy of debridement and biological amniotic membrane transplantation combined with subconjunctival injection of antifungal drugs for fungal keratitis.Methods Thirty nine eyes of 39 patients with fungal keratitis were enrolled in this study.The patients underwent corneal debridement combined with biological amniotic membrane transplantation.Subconjunctival injection of antifungal drugs and antifungal eye drops were used after operation.The follow up time was 3 to 6 months.The healing of corneal ulcer,amniotic membrane and visual acuity were investigated under slit lamp microscope.Results Corneal ulcer in 36 cases healed.3 patients underwent biological amniotic membrane transplantation again because of biological amniotic membrane falling off and corneal ulcer healed after transplantation and local antifungal drugs.Conclusion Debridement combined with biological amniotic membrane transplantation and antifungal drugs were effective for the treatment of fungal keratitis.