奥曲肽在晚期癌性肠梗阻治疗中的作用

Role of Octreotide in the Management of Advanced Malignant Bowel Obstruction

目的探讨奥曲肽在晚期癌性肠梗阻中的作用。方法晚期癌性肠梗阻非手术治疗患者100例分为2组:对照组50例接受常规治疗,治疗组50例在常规治疗的基础上,加用奥曲肽。观察2组鼻胃管引流量及鼻胃管拔除率。结果治疗第7天,治疗组鼻胃管引流量显著少于对照组,而鼻胃管拔除率显著高于对照组(P<0.05)。治疗组总有效率为92.0%,高于对照组的54.0%(P<0.05)。治疗组住院时间、呕吐缓解时间、腹痛缓解时间以及肛门排气时间均显著短于对照组(P<0.05)。结论奥曲肽用于晚期癌性肠梗阻的治疗能够提高疗效,减轻患者痛苦。

Objective To evaluate the role of octreotide in the management of advanced malignant bowe1 obstruction. Methods One hundred patients with inoperable malignant bowel obstruction were divided into two groups,50 patients in the control group received the routine treatments,while 50 patients in the treatment group received octreotide in addition to the routine treatments. The nasogastric tube drainage volume and the nasogastric tube simultaneously disconnect rate were observed in the two groups. Results Compared with the control group,the nasogastric tube drainage volume was lower and the nasogastric tube simultaneously disconnect rate was higher in the treatment group on the seventh day（ P 〈 0. 05）; the response rate in the treatment group（ 92. 0%） was higher than that in the control group（ 54. 0%）（ P 〈 0. 05）; the hospitalization time,the vomiting relief time,the abdominal pain relief time and the anal exhaust time in the treatment group were shorter than those in the control group（ P 〈0. 05）. Conclusion Octreotide is effective in the management of advanced malignant bowe1 obstruction,and can relieve the distress of the patient.