肾集合管癌临床病理分析

Clinicopathological Analysis of Renal Collecting Duct Carcinoma

目的探讨肾集合管癌的临床病理学特征。方法对2例肾集合管癌进行临床资料、组织病理和免疫表型分析,并复习相关文献。结果肾集合管癌位于肾髓质,镜下呈弥漫性腺管状排列,周围集合管可见异型增生,间质纤维组织反应性增生。免疫组化:AE1/AE3(+)、CK8/18(+)、CK19(+)、CD15(+)、CD10(-)、Villin(-)。结论肾集合管癌是一种少见的肾脏恶性上皮性肿瘤,诊断主要依据病理形态学特点,免疫组化对诊断可起一定的辅助作用。

Objective To explore the clinicopathological features of renal collecting duct carcinoma. Methods The clinical data,histopathological examination and immunohistochemical examination of 2 cases of renal collecting duct carcinoma were observed. Meanwhile,the relevant literatures were reviewed. Results Renal collecting duct carcinoma were located in the renal medulla. Under the microscope,these appeared diffuse tubular arrangement.Dysplasia and reactive hyperplasia of interstitial fibrous tissue can be found around the collectting tub. Immunohistochemical features： AE1 /AE3（ ＋）,CK8 /18（ ＋）,CD10（-）. Conclusion Renal collecting duct carcinoma is a kind of rare malignancy tumor,the diagnosis mostly depends on the clinical symptoms and histological features,the immunohistochemistry can be used when it is necessary.