版纳印奇果毒理学安全性研究

Toxicological Evaluation of the Safety of Sacha Inchi(Plukenetia volubilis linneo)

目的评价版纳印奇果的毒理学安全性.方法采用小鼠急性经口毒性试验、遗传毒性试验和大鼠30 d喂养试验对版纳印奇果的毒理学安全性进行评价.结果试验得知该样品对雌、雄性小鼠的急性经口毒性LD50分别为7 940和9 260 mg/kg.Ames试验、小鼠骨髓细胞微核试验以及小鼠精子畸形三项遗传毒性试验结果均为阴性.大鼠30 d喂养试验结果表明版纳印奇果可以导致大鼠的体重增长缓慢,并降低大鼠的食物利用率;导致大鼠肝、肾的绝对重量减小,并增大大鼠的肝体比、睾体比.对大鼠的各项血常规指标以及血清生化指标无显著影响;对大鼠的肝脏功能有一定的不良影响;病理组织检查结果显示,该样品对大鼠的肝脏具有明显的损害作用.结论该版纳印奇果样品在当前试验条件下具有一定的毒副作用.

Objective To evaluate the safety of sacha inchi （Plukenetia volubilis linneo） as a health food. Method Acute oral toxicity test, genetic toxicity tests, and rats 30 days feeding test were conducted to evaluate the safety of sacha inchi. Results LDS0 of sacha inchi were 7940 mg/kg BW for female mice and 9260 mg/kg BW for male mice. Results of the genetic tests, including the Ames test, bone marrow cells micronucleus assay, and the sperm abnormality test, were negative. Results of the 30 days feeding test showed that sacha inchi had negative effects on the weight gain, food utilization rate, blood count, and serum chemistries. Significant pathological injury in the liver of rats was observed. Conclusion Saeha inchi is toxic under the current experimental conditions.