68例盐酸米诺环素辅助治疗牙周-牙髓联合病变的临床疗效分析

Therapeutic Effect of Minocycline Hydrochloride as Adjunctive Therapy in 68 Cases of Periodontal-endodontic Combined Lesions

目的评价盐酸米诺环素(派丽奥)辅助治疗牙周-牙髓联合病变的疗效及临床意义.方法选择从2010年1月至2012年1月到昆明医科大学附属口腔医院急诊科就诊的牙周-牙髓联合病症的患者68例(92牙)作为研究对象,随机分为观察组(盐酸米诺环素治疗)34例(48牙)和对照组(碘甘油治疗)34例(44牙).通过常规根管治疗和牙周基础治疗后,分别用盐酸米诺环素药膏及碘甘油牙周给药治疗(每周1次),治疗4周后,分别比较2组在术后1个月,半年的疗效.结果观察组术后1个月和半年的总有效率分别为89.58%和86.95%,与对照组比较差异有统计学意义(P<0.05).结论应用盐酸米诺环素(派丽奥)辅助治疗牙周-牙髓联合病变具有良好的疗效.

Objective To evaluate the therapeutic effect and clinical significance of Minocycline hydrochloride （Periocline） as adjunctive therapy in periodontal-endodontie combined lesions. Methods Sixty-eight patients with Periodontal-endodontie combined lesions （92 teeth） who admitted to our department were selected as study object, and they were randomly divided into two groups： 34 patients （48 teeth） in observation group （Minocycline hydrochloride treatment） and 34 patients （44 teeth） control group （Iodine glycerol treatment ） . On the basis of routine root canal therapy and periodental non-surgical treatment, minocyeline hydrochloride and iodine glycerol were respectively given to patients in observation group and control group, one time every week and for 4 weeks. The therapeutic effect one month and half a year after treatment was compared between two groups. Results The total effective rates one month and half a year after treatment in observation group were 89.58% and 86.95%, respectively, which were significantly higher than those in the control group （P〈0.05） . Conclusion Minocycline hydrochloride （Periocline） as adjunctive therapy has good therapeutic effect on periodontal-endodontic combined lesions.