微创经皮肾镜取石术对上尿路结石患者血清及尿液炎性应激指标的影响

The Influence of Minimally Invasive Percutaneous Nephrolithotomy on the Serum and Urine Inflammatory Stress Indexes of Patients with Upper Urinary Tract Calculi

目的探讨观察微创经皮肾镜取石术对上尿路结石患者血清及尿液炎性应激指标的影响情况.方法选取2011年11月至2013年12月于西双版纳州人民医院进行治疗的84例上尿路结石患者为研究对象,84例患者遵循随机分配的原则分为对照组42例和观察组42例,对照组患者以腹腔镜切开取石术进行治疗,观察组患者则以微创经皮肾镜取石术进行治疗,然后将两组患者术前及术后1 d、3 d、5 d的血清及尿液炎性应激指标进行比较.结果观察组术后1d、3 d及5 d的血清及尿液IL-2高于对照组(P<0.05),其他血清及尿液炎性指标均低于对照组(P<0.05),且术后1 d及3 d均与术前及术后5 d差异有统计学意义(P<0.05).结论微创经皮肾镜取石术对上尿路结石患者血清及尿液炎性应激指标的影响相对较小,且恢复较快.

Objective To investigate and observe the influence of minimally invasive percutaneous nephrolithotomy on the serum and urine inflammatory stress indexes of patients with upper urinary tract calculi. Methods 84 patients with upper urinary tract calculi in our hospital from November 2011 to December 2013 were selected as the research object, and 84 patients were divided into control group （42 cases ） and observation group （ 42 cases ） by the random allocation, patients in the control group were treated with laparoscopic upper urinary lithotomy , and patients in the observation group were treated with minimally invasive percutaneous nephrolithotomy, then the serum and urine inflammatory stress indexes of two groups before operation and at first, third and fifth day after the operation were compared. Results The serum and urine IL-2 of observation group at first, third and fifth day after the operation were all higher than those of control group, and other serum and urine inflammatory stress indexes were all lower than those of control group, and those indexes at first and third day after the operation had obvious differences to the levels before the operation and at fifth day after the operation, all P〈0.05, there were all significant differences. Conclusion The influence of minimally invasive percutaneous nephrolithotomy on the serum and urine inflammatory stress indexes of patients with upper urinary tract calculi are relatively less, and its recovey is rapid.