摘要
MicroRNA(miRNA)是一类长约22nt的非编码小RNA,广泛存在于各种生物中,调节生物体生长、发育和凋亡等过程。研究表明,miRNA在人和动物睾丸发育及精子生成等过程也起着重要的调控作用。但miRNA在不同种属的睾丸组织及其不同发育时间段均存在特异性表达。此外,miRNA在动物精子生成过程中也存在时空特异性。文章综述了睾丸发育和精子生成过程中miRNA的差异性表达、表达调控以及一些miRNA对精子生成的调节作用,旨在为睾丸miRNA的进一步研究提供参考,为利用miRNA调控和促进种公畜精液品质提供研究思路。
MicroRNA （miRNA）, a class of non-coding RNA （about 22 nt）, widely exists in different organisms and plays an important role in regulating cell growth, development, and apoptosis. Recently, various studies have demonstrated that miRNA also serves as a key mediator during testis development and spermatogenesis both in human beings and animals. However, the expression of miRNA in different testis from different species showed significant differences. Meanwhile, it also showed different expression patterns in different spermatogenesis stages. In this review, we summarize different miRNA expression patterns during testis development, spermatogenesis, as well as their roles in regulating spermatogenesis,which provids insight into the further research on miRNA in testis, and ideas for regulating and improving animal sperm quality by using miRNA.
出处
《遗传》
CAS
CSCD
北大核心
2014年第7期646-654,共9页
Hereditas（Beijing)
基金
国家现代农业产业技术体系建设专项资金(编号:CARS-36)资助
