microRNA调控肿瘤细胞能量代谢机理的研究进展

Research Progress of The Regulation of Energy Metabolism in Tumor Cells by MicroRNA

目的总结近年来microRNA对肿瘤细胞能量代谢调控的最新研究进展。方法根据PUBMED检索获取的相关资料,就近年来关于microRNA对肿瘤细胞能量代谢调控机理的研究进展进行综述。结果有氧糖酵解(Warburg效应)是恶性肿瘤最主要的能量代谢特点,microRNA能够通过对肿瘤细胞葡萄糖摄取、糖酵解途径、三羧酸循环以及脂代谢和氨基酸代谢与三羧酸循环的联系等途径中的关键环节进行调控,结果使肿瘤细胞对葡萄糖的摄取和糖酵解处于增高状态。可见,葡萄糖、脂肪酸、氨基酸转运和代谢对肿瘤细胞至关重要,且与肿瘤患者的不良预后有关。结论研究microRNA对肿瘤细胞能量代谢的调控,为破解肿瘤细胞基于能量代谢异常而表现出的恶性生物学行为提供了重要线索,也为肿瘤的诊断和治疗提供了有力的证据及新的思路和途径。就目前关于microRNA对肿瘤细胞能量代谢调控方面的研究进展来看,必须要揭示清楚的是microRNA异常表达引起肿瘤细胞代谢变化后,能够直接引发肿瘤生物学行为变化的肿瘤细胞代谢因素有哪些。

Objective To summarize the research progress of bioenergetic metabolic mechanisms regulated of tumor cells by microRNA in recent years. Methods Literatures about the recent studies on the bioenergetic metabolic mechanisms regulated of tumor cells by microRNA were reviewed according to the results searched from PUBMED.Results Aerobic glycolysis （Warburg effect） is the most significant characteristics of bioenergetic metabolism in tumor cells. MicroRNAs can regulate many key progressions involved in tumor cells bioenergetic metabolism， such as uptake of glucose， glycolytic pathway， tricarboxylic acid cycle （TAC）， and the relationship among lipid metabolism， amino acid metabolism and TAC， resulting in accelerated uptake of glucose and glycolysis. Thus we believe that the transportation and metabolic procession are vital important for tumor cells and related to poor prognosis of patients. Conclusions The studies on relationship between microRNA and bioenergetic metabolism have come an important insight for malignant biological behavior of tumor cells based on abnormal bioenergetic metabolism and also become new and important supplementary means of diagnosis and treatment of cancer. As far as the research progress about tumor cells bioenergetic metabolism regulated by microRNA， one of the things must be revealed is that which metablic factors can directly change tumor biological behavior after tumor cells bioenergetic metabolism changed caused by microRNA.