不同平台对大鼠Morris水迷宫学习记忆能力的影响

Effects of different platforms on the learning and memory capability of rats in the Morris water maze

目的探讨水迷宫不同形状逃避平台对大鼠学习记忆能力的影响。方法选用44只健康雄性SD大鼠,利用Morris水迷宫装置检测学习记忆能力,并观察两种不同形状(圆柱形和杆状)逃避平台对大鼠学习记忆的影响。结果逃避潜伏期结果显示,两种平台潜伏期无统计学差异(P>0.05);空间探索实验结果也无统计学差异(P>0.05)。结论两种形状逃避平台对大鼠学习记忆能力无明显影响。

Objective To study the effects of platforms with different shapes on learning and memory capability using the Morris water maze. Methods Morris water maze was used to detect learning and memory capability of 44 healthy male SD rats. Two escape platforms with different shapes（cylinder or rod） were used to investigate the effects of different platforms on learning and memory capability. Results The data of escape latency showed no significant difference （ P 〉 0.05 ）. There was no significant difference in probe trial （ P 〉 0.05 ）. Conclusion Platforms with different shapes do not affect the learning and memory capability in Morris water maze.