GRK6在胃癌中的表达及其预后价值

Expression of GRK6 in gastric carcinoma and its prognostic value

目的通过检测G蛋白偶联受体激酶6(G protein coupled receptor kinase 6,GRK6)在胃癌中的表达情况,探讨其与相关临床病理参数及生存预后的关系。方法通过组织芯片及免疫组化技术,检测132例胃恶性肿瘤及8例胃良性疾病中GRK6的表达情况,统计学分析影响GRK6表达情况的相关因素,并根据相关随访资料,探讨GRK6表达与患者预后的关系。结果 GRK6在120例胃恶性肿瘤中高表达率为49.17%,低表达率为50.83%,多因素Logistic回归分析表明GRK6的表达与肿瘤分化相关(P<0.05)。GRK6高表达患者的5年存活率为28.81%,低表达者的5年存活率为67.21%,差异有统计学意义(P<0.05)。Cox生存预后分析提示GRK6的表达及术后有无治疗为影响胃癌患者预后的独立因素(P<0.05)。结论 GRK6在胃腺癌中的表达程度与肿瘤的分化情况密切相关,高表达者的5年生存率明显低于低表达者,为胃癌患者的不良预后指标,可能在胃癌发生发展中起重要作用。

Objective To investigate the expression of G protein coupled receptor kinase 6（ GRK6） in gastric carcinoma in order to examine its correlation with the clinicopathologial parameters and prognosis of gastric cancer. Methods GRK6 expressions in 132 malignant gastric carcinoma cases and 8 benign cases were detected with tissue microarray and immunohistochemistry technique. Relevant factors influencing GRK6 expression were analyzed statistically. Association between GRK6 expression and prognosis of gastric cancer was evaluated with reference to follow-up data. Results The high expression rate of GRK6 in gastric carcinoma was 49. 17%,and the low expression rate was 50. 83%. Multivariate logistic regression analysis disclosed that there was correlation between GRK6 expression and poor differentiation（ P 〈0. 05）. The 5-year overall survival rates of patients with high and low GRK6 expressions were 28. 81% and 67. 21%,respectively（ P 〈0. 05）. Multivariate Cox regression analysis showed that GRK6 was an independent prognostic factor of gastric cancer（ P 〈0. 05）. Conclusion GRK6 expression in gastric carcinoma is significantly higher than in benign cases. The overexpression of GRK6 is closely correlated with histological differentiation. GRK6 may play an important role in the occurrence and development of gastric carcinoma.