2010年～2012年某区127株淋球菌抗生素敏感性的分析

The Analysis of Antimicrobial Susceptibility of 127 Neisseria Gonorrhoeae in A District from 2011~2012

目的了解江门地区2010年~2012年淋球菌对抗生素的敏感性及变化趋势。方法采用琼脂稀释法测定6种抗生素对127株淋球菌的最小抑菌浓度（MIC）及质粒介导的高度耐四环素淋球菌（TRNG）,采用纸片酸度法检测菌株是否产β-内酰胺酶（PPNG）。结果淋球菌对大观霉素及头孢克肟的敏感率均为100%,头孢曲松为77.95%,环丙沙星敏感率最低,其耐药率高达92.13%;127株淋球菌中检出PPNG菌株48株（37.80%）,TRNG菌株51株（40.16%）。结论淋球菌对青霉素、四环素和环丙沙星的耐药率较高,大观霉素及头孢克肟可作为治疗本地区淋病的首选药物。

Objective To survey the susceptibility and trend of Neisseria gonorrhoeae to antibioticagets in Jiangmen from 2010 to 2012.Methods 127 Neisseria gonorrhoeae strains were observed for their susceptibility to six antibiotics, agard lution method was used to detect minimal inhibitory concentration （MIC） of antimicrobial agents and high-level tetracycline-resistance of Neisseria gonorrhoeae（TRNG）,the production ofβ-lactamase was dectermined by paper acidometric method. Results The percentage of Neisseria gonorrhoeae strains sensitive to Spectinomycin,cefixime and ceftriaxone was 100%,100%and 77.95%,the percentage of Neisseria gonorrhoeae strains resistent to ciprofloxacin was 92.13%;48（37.80%） strains were penicillinase-producing Neisseria gonorrhoeae （PPNG）,51（40.16%） strains were TRNG. Conclusion The Neisseria gonorrhoeae isolates are highly resistant to penicillin,tetracycline and ciprof loxacin,spectinomycin and cefixime should be used the first-line drugs for the treatment of Neisseria gonorrhoeae in Jiangmen.