美沙拉嗪对活动性溃疡性结肠炎的疗效观察

Observation of the curative effect of mesalazine on active ulcerative colitis

目的:考察美沙拉嗪对活动性溃疡性结肠炎患者炎症相关因子和血小板计数的影响。方法:将89例活动性溃疡性结肠炎患者分为观察组(美沙拉嗪肠溶片治疗,45例)和对照组(柳氮磺胺吡啶治疗,44例),比较两组治疗效果和不良反应发生情况。结果:治疗后,观察组患者治疗有效率(93.33%)明显高于对照组(70.45%),而观察组炎症指标(IL-6、IL-1、TNF-α)和血小板计数均明显低于对照组,两组比较差异具有统计学意义(P<0.05),且全部患者治疗后的上述指标水平较治疗前均明显降低,治疗前后比较差异均具有显著性(P<0.05);治疗过程中,观察组不良反应发生比例明显低于对照组(P<0.05)。结论:美沙拉嗪对活动性溃疡性结肠炎具有确切的治疗效果,可明显降低患者炎症因子水平和抑制血小板活化状态。

Objective： To study the effect of mesalazine on inflammation-associated cytokines and platelet count in patients with active ulcerative colitis. Methods： Eighty-nine cases of patients with active ulcerative colitis were divided into an observation group （treated with mesalazine tablets, n=45） and a control group （treated with sulfasalazine, n=44） and the effects and adverse reaction were compared between two groups. Results： After treatment, the efficiency was significantly higher in the observation group （93.33%） than in the control group （70.45%）, and the inflammation markers such as IL-6, IL-1, TNF- ~t and the platelet count were significantly lower in the observation group than in the control group （P〈0.05）, moreover, index levels above- mentioned in all patients were significantly decreased after treatment as compared with those before treatment （P〈0.05）. Adverse reaction was significantly lower in the observation group than in the control group （P〈0.05） during treatment. Conclusion： Mesalazine has a good effect in the treatment of active ulcerative colitis and can significantly decrease the levels of inflammatory factors and inhibit the activation of platelet in patients.