奥曲肽与小剂量垂体后叶素在血吸虫性肝硬化继发食管曲张静脉出血中的应用

Application of octreotide combined with small dose of pituitrin in the treatment of schistosoma cirrhosis with esophageal variceal hemorrhage

目的:探讨奥曲肽与小剂量垂体后叶素在血吸虫性肝硬化腹水继发食管曲张静脉出血中的疗效。方法:按随机数字表法随机选取我院2013年1月-2014年1月血吸虫性肝硬化腹水继发食管静脉出血患者75例,随机将其分为两组,小剂量组(38例)采用奥曲肽联合小剂量垂体后叶素治疗,常规组(37例)采用奥曲肽联合常规剂量垂体后叶素治疗,比较两组患者治疗效果。结果:小剂量组与常规组总有效率、平均止血时间和平均出血量比较差异无统计学意义,小剂量组不良反应发生比例明显低于常规组,两组比较差异具有显著性。结论:奥曲肽联合小剂量垂体后叶素较奥曲肽联合常规剂量垂体后叶素治疗血吸虫性肝硬化继发食管静脉出血的效果相当,但不良反应更少,值得临床推广使用。

Objective： To study the efficacy of octreotide combined with small dose of pituitrin in the treatment of schistosoma cirrhosis with esophageal variceal hemorrhage. Methods： Seventy-five patients with schistosoma cirrhosis with esophageal variceal bleeding hospitalized from January 2013 to January 2014 in our hospital were divided by random number table into a small dose group（38 cases, treated with octreotide combined with a small dose of pituitrin） and a conventional group（37 cases, treated with octreotide combined with a conventional dose of pituitrin）. The clinical efficacy were compared between two groups. Results： Comparisons in the total effective rate, average hemostasis time and the average amount of bleeding between two groups showed no statistical significance while the incidence of adverse reactions was lower in the small dose group than in the conventional group, which was statistically significant. Conclusion： Octreotide combined with the small dose of pituitrin has a comparable efficacy with the conventional dose of pituitrin in the treatment of schistosoma cirrhosis with esophageal variceal hemorrhage but with a lower incidence of adverse reactions, which is worthy of clinical use.