白芍总苷联合窄谱中波紫外线及卡泊三醇治疗中度寻常性银屑病78例疗效分析

Observation on the Efficacy of TGP Capsule Combined with NB-UVB and Calcipotriol in the Treatment of Moderate Psoriasis Vulgaris

目的观察白芍总苷(total glucosides of paeony,TGP)联合窄谱中波紫外线(narrow band ultraviolet B light,NB-UVB)、卡泊三醇治疗中度寻常性银屑病的临床疗效和安全性。方法 154例中度寻常性银屑病患者随机分为治疗组78例和对照组76例。两组给予NB-UVB每周3次照射和卡泊三醇乳膏每日2次外用治疗,此外,治疗组给与白芍总苷胶囊600mg口服,3次/d。两组疗程均为8周。以银屑病皮损面积和严重程度(PASI)评分评价疗效并记录不良反应。结果治疗8周后,治疗组PASI评分(2.1±0.8)低于对照组(5.3±1.4),差异有统计学意义(P<0.05);治疗组有效率(88.46%)高于对照组(73.68%),差异有统计学意义(P<0.05)。两组未见明显不良反应。结论 TGP联合NB-UVB、卡泊三醇治疗中度寻常性银屑病疗效好,安全性高。

Objective To observe the efficacy and safety of TGP capsule combined with narrow-band ultraviolet B and calcipotriol in the treatment of moderate psoriasis vulgaris. Methods One hurdred and fifty-four pa- tients with moderate psoriasis vulgaris were divided randomly into treatment group （N = 78 ） and control group （N =76） for 8 weeks. Two groups were treated with NB-UVB three times a week and calcipotriol ointment twice daily, plus TGP capsule 600mg,3 times a day only in the treatment group. Therapeutic effect of both groups were evaluated after 8 weeks by psoriasis area and severity index （PASI）. Results The PASI score in the treatment group （2. 1 ± 0. 8） was significantly lower （ P 〈 0. 05 ） than that of the control group （5.3 ±1.4）. The efficacy rate in the treatment group （88.46%） was significantly higher than that of the control group （73.68%） （P 〈 0. 05 ）. No adverse reaction occurred. Conclusion TGP capsule combined with NB-UVB and calcipotriol in the treatment of moderate psoriasis vulgaris indicated good efficacy and safety for moderate psoriasis.