住院患者抗菌药物临床应用干预前后对比分析

Clinical use of antibiotics of hospitalized patients before and after intervention:a comparative study

目的分析医院住院患者1个月的抗菌药物应用,评价用药合理性,调查其干预效果,为抗菌药物临床合理应用以及管理提供参考依据。方法 2011年5月全院出院患者3 446例作为对照组,2012年5月全院出院患者3 787例作为干预组,比较两组抗菌药物使用率以及使用强度,采用SPSS13.0分析。结果活动前抗菌药物使用金额占药品总金额的27.3%,抗菌药物使用率为77.7%,抗菌药物累计使用DDDs 28 384.9,使用强度74.1,特殊使用抗菌药物构成比14.8%,限制使用抗菌药物构成比39.3%;活动后抗菌药物使用金额占10.7%;抗菌药物使用率为47.6%;抗菌药物累计使用DDDs 21 477.1,使用强度52.9,特殊使用抗菌药物构成比6.7%,限制使用抗菌药物构成比15.2%。结论经过抗菌药物专项整治活动,医院抗菌药物临床应用渐趋合理,抗菌药物使用率、使用量明显下降,使用强度也有明显下降;特殊使用与限制使用抗菌药物的比重有大幅度下降,但仍有不合理使用抗菌药物现象,使用强度达不到卫生部要求(AUD<40DDD)。

OBJECTIVE To investigate the use of antibiotics of the hospitalized patients within one month,evaluate the rationality of medication,and observe the effects of interventions so as to provide guidance for reasonable clinical use of antibiotics.METHODS Totally 3446 patients who were discharged in May 2011 were assigned as the control group,3787 patients who were discharged in May 2012 were set as the intervention group,then the utilization rate of antibiotics and the use intensity were observed and compared between the two groups,and the statistical analysis was performed with the use of SPSS13.0 software.RESULTS Before the intervention,the percentage of amount of use of antibiotics and the total amount of drugs was 27.3%,the utilization rate of antibiotics was77.7%,the cumulative DDDs of antibiotics was 28 384.9,the use intensity was 74.1DDD,the constituent ratio of use of special antibiotics was 14.8%,the constituent ratios of use of restricted antibiotics was 39.3%.After the intervention,the percentage of amount of use of antibiotics and the total amount of drugs was 10.7%,the utilization rate of antibiotics was 47.6%,the cumulative DDDs of antibiotics was 21 477.1,the use intensity was 52.9DDD,the constituent ratio of use of special antibiotics was 6.7%,and the constituent ratio of use of restricted antibiotics was 15.2%.CONCLUSION The clinical use of antibiotics tends to be reasonable through special rectification,the utilization rate of antibiotics and use dosage as well as use intensity are also significantly reduced.There is substantial decline in the proportion of use of special antibiotics or restricted antibiotics,the unreasonable use of antibiotics remains,and the use intensity dose not meet the requirements of the Ministry of Health（AUD40DDD）.