新生儿侵袭性真菌感染临床分析

Clinical analysis on neonatal invasive fungal infections

目的研究分析新生儿侵袭性真菌感染的临床特征,为合理的诊治提供参考依据。方法选取2012年4月-2013年4月共76例侵袭性真菌感染新生儿的病例,观察并分析侵袭性真菌感染的病原菌、影响因素以及临床表现特征,并记录试验室的转归情况。结果 76例新生儿侵袭性真菌感染均为假丝酵母菌属感染,侵袭性真菌感染早产儿62例占81.6%,其中极低出生体质量儿21例,超低出生体质量儿9例。结论新生儿侵袭性真菌感染的病原菌主要是假丝酵母菌属感染,侵袭性真菌感染的发生,与患儿的机体状态、原发病以及并发症有密切的联系;规范抗菌药物的应用、掌握呼吸机应用指征以及尽早过渡至肠内营养等,均是预防新生儿侵袭性真菌感染的有效措施。

OBJECTIVE To analyze clinical features of neonatal invasive fungal infections,so as to provide a reasonable basis for reasonable diagnosis and treatment.METHODS A total of 76 patients with neonatal invasive fungal infection during Apr.2012 to Apr.2013 were selected.Pathogens of invasive fungal infections,influencing factors and clinical features were observed and analyzed,and the outcomes in the laboratory were recorded.RESULTS All the 76 cases of invasive fungal infections were due to Candida albicans.There were 62 cases of premature children with invasive fungal infections,accounting for 81.6%,including 21 very low birth weight infants,and 9extremely low birth weight infants.CONCLUSION The primary pathogen of neonatal invasive fungal infections was C.albicans.The occurrence of invasive fungal infections is closely related to children＇s body status,primary disease and complications.To regulate the application of antibiotics,master indications of respirator,and early transit to enteral nutrition are effective measures to prevent neonatal invasive fungal infections.