神经节苷脂治疗新生儿缺氧缺血性脑病49例

Effect of Monosialoganglioside in Treating Neonatal Hypoxic-Ischemic Encephalopathy in 49 Cases

目的：观察分析单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病（HIE）的疗效。方法选取诊断为新生儿 HIE 的患儿98例，随机分为对照组和治疗组，各49例。两组均给予常规对症支持治疗，治疗组加用神经节苷脂20 mg / d，静脉滴注，1次/日，14 d 为1个疗程，根据病情应用1~3疗程。比较2种治疗方法的效果。结果治疗组患儿在意识障碍恢复、惊厥停止、反射与肌张力恢复正常的时间上明显短于对照组，临床治疗总有效率明显高于对照组（ P ﹤0.05）。结论应用神经节苷脂对促进新生儿 HIE 中枢神经系统功能恢复作用明显，能有效减轻临床症状，缩短病程，提高治愈率，值得临床推广。

Objective To observe the effect of monosialoganglioside for treating neonatal hypoxic - ischemic encephalopathy （ HIE ） . Methods 98 patients with neonatal HIE were selected and randomly divided into the control group and the treatment group, 49 cases in each group. The two groups were given the routine symptomatic supportive treatment. On this basis, the treatment group was added with monosialoganglioside 20 mg by intravenous drip, once daily with 14 d as one course of treatment. 1 - 3 courses of treatment were applied according to the disease condition. The effects were compared between these two kinds of treatment therapy. Results The con-scious disturbance recovery time, convulsion stop, time of reflect and muscular tension recovery to normal in the treatment group were sig-nificantly shorter than those in the control group, the clinical total effective rate in the treatment group was significantly higher than that in the control group（ P ﹤ 0. 05）. Conclusion Monosialoganglioside has obvious effect for promoting the central nervous system （ CNS） func-tion recovery in neonatal HIE, and can effectively relieve the clinical symptoms, shorten the course of disease, increase the cure rate, which is worthy of clinical promotion.