曲安奈德联合磷酸氯喹治疗口腔扁平苔藓30例

Clinical Effect of Triamcinolone Acetonide Combined with Chloroquine Phosphate in Treating 30 Cases of Oral Lichen Planus

目的观察曲安奈德联合磷酸氯喹治疗口腔扁平苔藓的临床疗效。方法收集2012年1月到2013年1月收治的60例口腔扁平苔藓患者的临床资料,将患者随机分为观察组和对照组,各30例。对照组单纯采用磷酸氯喹治疗,观察组采用曲安奈德联合磷酸氯喹治疗,分析两组患者的治疗效果。结果观察组的总有效率为93.34%,明显高于对照组的73.33%(P<0.05)。观察组不良反应发生率为6.67%,明显低于对照组的13.33%(P<0.05)。观察组患者治疗后疼痛评分、血清IgM,IgG水平明显优于对照组(P<0.05)。结论曲安奈德联合磷酸氯喹治疗口腔扁平苔藓,有利于降低口腔疾病复发率,安全性与有效性显著,值得临床推广。

Objective To observe the clinical effect of triamcinolone acetonide combined with chloroquine phosphate in treating oral lichen planus. Methods The clinical data in 60 cases of oral lichen planus treated in our hospital from January 2012 to January 2013 were collected and the patients were randomly divided into the observation group and the control group, 30 cases in each group. The control group adopted the simple chloroquine phosphate treatment, while the observation group was treated with triamcinolone acetonide combined with chloroquine phosphate. Finally the therapeutic effects in the two groups were analyzed. Results The total effective rate was 93. 34% in the observation group, which was significantly higher than 73. 33% in the control group（ P ﹤ 0. 05）. The occurrence rate of adverse reactions was 6. 67% in the observation group, which was obviously lower than 13. 33% in the control group（ P ﹤ 0. 05）. The pain score, levels of serum IgM and IgG in the observation group were significantly superior to those in the control group（ P ﹤ 0. 05 ） . Conclusion Triamcinolone acetonide combined with chloroquine phosphate in treating oral lichen planus is helpful to reduce the recur-rence of oral diseases, has significant safety and effectiveness, which is worthy of clinical promotion.