^(131)I-MIBG前体间碘苄胍硫酸盐的合成工艺改进

Synthesis of Metaiodobenzylguanidine Sulfate as the Precursor of ^(131)I-MIBG

设计一条以3-碘苄溴为起始原料,经间碘苄胺合成间碘苄胍,最终碘标记得^(131)IMIBG。此法原料易得,工艺简便。

Using 3-iodo-benzyl bromide as the starting material, via 3-iodo-benzylamine, metaiodoben-zylguanidine sulfate, a precursor of 131I-MIBG, was obtained after a 4-step reaction. This synthesis method is simple, under mild conditions, practical and feasible.