磷酸肌酸钠治疗小儿病毒性心肌炎的临床疗效

Clinical Effect of Creatine Phosphate Sodium for Injection on Acute Viral Myocarditis of Children

目的:探讨磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及安全性。方法:选取2011年2月至2013年2月在我院就诊的病毒性心肌炎患儿128例。其中62例患儿予以常规护心治疗作为对照组;66例患儿在普通护心治疗基础上加用磷酸肌酸钠作为观察组。治疗2周后,复查心肌酶,以及观察临床症状、体征、心电图的恢复情况。结果:治疗后,观察组、对照组的总有效率差异虽无统计学意义(96.9%vs 93.5%,P>0.05);但显效率(57.6%vs 33.9%,P<0.01)及心肌酶指标(肌酸激酶及肌酸激酶同工酶,P<0.05)的改善差异有显著意义。结论:加用磷酸肌酸钠治疗小儿病毒性心肌炎,具有一定的疗效。

To observe the curative effect and safety of Creatine Phosphate Sodium for Injection in the treatment for acute viral myocarditis of children. Methods： From Feb. 2011 to Feb. 2013, 128 cases of viral myocarditis in our hospital were divided in two groups, 66 cases （reviewing group） received Creatine Phosphate Sodium for Injection plus common treatment, while the other 62 cases （control group） received common treatment only. The amelioration of myocardial enzymes, clinical symptom and electrocardiogram were observed. Result： Although there was no difference in the total effective rate （96.9% vs 93.5%, P〉0.05）, the significant efficiency （57.6% vs 33.9%, P〈0.01）, the amelioration of creatine kinase and CK-MB （P〈0.05） of the reviewing group were significantly improved compared with those of the control group. Conclusion： Creatine Phosphate Sodium plus common treatment has positive effect on the acute viral myocarditis of children.