当归四逆汤中药熏蒸治疗糖尿病周围神经病变40例临床观察

A Clinical Observation of the Treatment of 40 DPN Cases through Fumigation of Danggui Sini Decoction

目的观察当归四逆汤中药熏蒸联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效。方法选取2013年6-12月就诊的80例DPN患者,随机分为对照组和实验组,对照组在控制血糖良好的基础上加用甲钴胺治疗,实验组在此基础上加用当归四逆汤中药熏蒸,连续治疗2周,观察2组患者治疗前后的神经传导速度、震动感觉阈值的变化,并比较2组患者的临床疗效。结果治疗后2组患者的神经传导速度及震动感觉阈值较治疗前均有改善(P<0.05),但实验组在治疗后各观察指标明显优于对照组(P<0.05)。实验组临床总有效率为90.0%,对照组总有效率为80.0%,2组比较差异有统计学意义(P<0.05)。结论当归四逆汤中药熏蒸联合甲钴胺治疗DPN可以明显改善神经传导速度,并提高临床疗效。

Objective To observe the clinical effect of treating DPN through the fumigation of Danggui Sini Decoction in combination with Mecobalamin. Method To select 80 cases of DPN patients having received medical treatment in a period from June 2013 to December 2013, and divide them into comparison group and experiment group at random. Those of the former group were treated by injections of Mecobalamin monitored by stable blood sugar control, while those of the latter group were given fumigation of Danggui Sini Decoction besides the same treatment of the former group. The treatments for both groups lasted for two weeks after which nerve conductive velocity and changes in the threshold value of sensing tremble before and after the treatments were observed and the clinical effects of the two groups were compared. Results The nerve conductive velocity and the threshold value of sensing tremble for both groups were improved in the wake of the treatments as compared with the state prior to the treatments （P〈0.05）, while the varied post-treatment outcome measures of the experiment group were markedly superior to those of the comparison group （P〈0.05）. The overall effective rate for the experiment group was 90.0%, while that of the comparison group was 80.0%, and the comparative differences of the two groups were statistically significant （P〈0.05）. Conclusion Treating DPN through the fumigation of Danggui Sini Decoction in combination with Mecobalamin can markedly improve nerve conductive velocity and the clinical effect.