小剂量干扰素抗病毒治疗慢性丙型肝炎肝硬化失代偿期的临床疗效

The clinical efficacy of small doses of interferon antiviral in treatment of chronic hepatitis with decompensated cirrhosis

目的探讨小剂量干扰素抗病毒治疗慢性丙型肝炎肝硬化失代偿期的临床疗效。方法选取2012年6月～2013年6月我院收治的慢性丙型肝炎肝硬化失代偿期患者40例．所有患者均给予利巴韦林．同时给予小剂量干扰素，治疗后随访24周。结果40例患者中有29例坚持抗病毒治疗，其中17例治疗24周，12例治疗48周。治疗后，29例患者纳差和腹胀症状均得到不同程度的缓解。24周时患者的肝功能（ALT、AST、ALB、TB）指标、凝血指标（PTA）以及病毒学指标均有明显的改善，与治疗前比较差异具有统计学意义（P〈0．05）；治疗72周和48周时比较，肝功能（ALT、AST、ALB、TB）指标、凝血指标（PTA）以及病毒学指标均无显著变化，两者比较差异无统计学意义（P〉0．05）。结论慢性丙型肝炎肝硬化失代偿期应用小剂量干扰素进行抗病毒治疗具有较好的疗效，能改善患者的肝功能。

Objective To study the clinical efficacy of small doses of interferon antiviral in treatment of chronic hepatitis with decompensated cirrhosis. Methods Forty cases with chronic hepatitis with decompensated cirrhosis were selected from our hospital during the period from June 2012 to June 2013,all patients were given ribavirin and small doses of interferon, all patients were followed up 24 weeks after treatment. Results Twenty-nine cases of 40 patients were insisted in antiretroviral therapy, 17 patients were treated for 24 weeks, 12 patients were treated for 48 weeks. After treatment, the anorexia and bloating symptoms of 29 patients were vary degrees of ease. The liver function index （ALT,AST, ALB,TB）,coagulation （PTA） and virological indicators in 24 weeks were significantly improved,the difference was statistically significant （P〈0.05）; 72 weeks compared with 48 weeks,the liver function index （ALT,AST,ALB, TB）, coagulation （PTA） and virological indicators had no significantly improved,the difference was not statistically significant （P〉0.05）. Conclusion Interferon antiviral has better clinical effect in treatment of chronic hepatitis,and it can improve the liver function.