磁性壳聚糖纳米微粒合成工艺的优化

Optimization of Synthesis Technology of Magnetic Chitosan Nanoparticles

目的:优化磁性壳聚糖纳米微粒的制备工艺。方法:用正交设计方法,考察乳液聚合法合成磁性壳聚糖纳米微粒的4个关键因素:壳聚糖与四氧化三铁的重量比、乳化剂用量、交联剂用量和乳液的水油比。用扫描电表征磁性壳聚糖纳米微粒。结果:磁性壳聚糖纳米微粒最佳工艺条件为:壳聚糖与四氧化三铁重量比为1∶1,乳化剂用量为0.6mL,交联剂用量为4mL,水相与油相体积比为20∶35。磁性壳聚糖纳米微粒平均直径为50nm左右。结论:该最优级工艺得率最高,纳米微粒均匀,已达到相对最优条件。

Objective：To optimize the preparation technology of magnetic chitosan nanoparticles.Methods：using the orthogonal design method,4 key factors of synthesis of magnetic chitosan nanoparticles were：water oil emulsion polymerization of chitosan and ferroferric oxide weight ratio,emulsifier,crosslinking agent and emulsion ratio.By scanning electrical characterization of magnetic chitosan nanoparticles.Results：the optimum conditions of magnetic chitosan nanoparticles：Chitosan and ferroferric oxide weight ratio of 1∶ 1,emulsifier dosage is 0.6mL,the amount of crosslinking agent 4mL,aqueous phase and oil phase volume ratio is 20∶ 35.Magnetic chitosan nanoparticles with an average diameter of about 50 nm.Conclusion：the optimal process was the highest,nano particles evenly,has achieved a relatively optimal conditions.