血清肝纤四项检测在原发性肝癌诊断中的应用

Role of 4 serum liver fibrosis biomarkers in the diagnosis of primary liver cancer

目的探讨血清肝纤4项检测在原发性肝癌诊断中的应用。方法采用化学发光法检测46例原发性肝癌、51例转移性肝癌、46例肝外恶性肿瘤患者和50名健康体检人员血清Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)和透明质酸(HA)的含量。结果原发性肝癌组PCⅢ、Ⅳ-C、LN和HA水平高于转移性肝癌组和肝外恶性肿瘤组(P<0.05),且三者都明显高于健康对照组(P<0.01)。结论肝纤4项指标与原发性肝癌关系密切,血清肝纤4项检测对原发性肝癌肝纤维化程度的判断、鉴别转移性肝癌有一定的价值。

Objective To investigate the application of 4 serum liver fibrosis biomarkers in the diagnosis of hepatic cancer. Methods The levels of serum protein collagen Ⅳ（ PC Ⅳ） , collagen Ⅳ （ Ⅳ-C ）, Laminin （LN） and hyaluronic acid （HA） were detected by ECLI in 46 cases of primary cancer, 51 cases of metastatic liver cancer, 46 cases of extra-hepatic malignant tumor and 50 health examinees. Results The levels of PC m, Ⅳ-C, LN and HA in the patients of the primary liver cancer group were all higher than those of the metastatic liver cancer group and the extra-hepatic malignant tumor group （ P 〈 0.05 ） , and the detected data of the above 3 groups were all significantly higher than those of the control group （ P 〈 0.01 ）. Conclusion The 4 serum liver fibrosis biomarkers were closely associated with primary liver cancer, and the detection of the 4 serum liver fibrosis biomarkers was valuable to the judgment of the seriousness of hepatic fibrosis in primary liver cancer and the identification of metastatic liver cancer.