阿莫西林分散片治疗上呼吸道感染的药代动力学分析

The analysis of pharmacokinetics of amoxicillin dispersible tablets in the treatment of respiratory tract infections

目的分析阿莫西林分散片在治疗上呼吸道感染患者时药物代谢动力学变化。方法选取156例上呼吸道感染患者为研究对象,采用数字表法随机分为观察组和对照组各78例,对照组口服阿莫西林胶囊,观察组口服阿莫西林分散片。监测两组患者的血药浓度及治疗效果。结果观察组患者服药后,最大血药浓度(732.5±60.84)μg/L、血药浓度下面积(6 340.2±170.36)明显高于对照组(P<0.05),达峰时间(2.7±0.65)h、分布半衰期(4.6±1.19)h明显快于对照组(P<0.05);观察组总有效率(96.15%)明显高于对照组(P<0.05)。结论采用阿莫西林分散片治疗上呼吸道感染患者,血药浓度高、达峰时间短、起效快、疗效确切,有较高的临床应用价值。

Objective To analyze pharmacokinetic changes of amoxicillin dispersible tablets in the treatment of patients with upper respiratory tract infection. Methods One hundred fifty-six cases of upper respiratory tract infection were randomly divided into observation group（ n= 78） and control group（ n = 78） using digital table method. Control group was treated with oral amoxicillin capsules,observation group was treated with oral amoxicillin dispersible tablets. Plasma drug concentration and therapeutic effects of two groups of patients were monitored. Results The peak concentration（ 732. 5 ± 60. 84 μg /L） and AUC（ 6 340. 2 ± 170. 36） were significantly higher in observation group than control group（P〈 0. 05）. The Tmax（ 2. 7 ± 0. 65 h） and half-life（ 4. 6 ± 1. 19 h） were obviously shorter than the control group（ P 〈 0. 05）. The total effective rate of observation group（ 96. 15%） was significantly higher than the control group（ P 〈 0. 05）. Conclusion For the treatment of patients with upper respiratory tract infection,amoxicillin dispersible tablet displays higher plasma drug concentration and shorter Tmax in comparison with amoxicillin capsules.