扩张型心肌病合并肺动脉高压的临床特点分析

Clinical analysis in patients of dilated cardiomyopathy combined with pulmonary hypertension

目的 探讨扩张型心肌病（DCM）合并肺动脉高压的临床特征.方法 连续选取我院诊断DCM的住院患者98例,根据超声数据分为正常肺动脉压组（43例）和肺动脉高压组（55例）.回顾性分析两组的一般资料、生化和超声心动图等检查数据.结果 肺动脉高压组一般资料与正常组患者比较差异均无统计学意义.超声心动图检查肺动脉高压组患者的左心室舒张末径、左心房内径、右心室内径显著大于正常组[分别为（72.36±11.14）mm比（66.82±10.54）mm、（51.76±9.25）mm比（43.13±8.93）mm和（27.93±6.85）mm比（21.47±5.09）mm,P均＜0.05],左心室射血分数显著低于正常组[（28.51±9.36）％比（35.73±10.51）％,P＜0.05],脑利钠肽（BNP）水平显著高于正常组[（1254.73±569.36）ng/ml比（573.26±257.14） ng/ml,P＜0.05].结论 DCM合并肺动脉高压的患者心脏扩张较显著,心功能更差,临床预后可能较差.

Objective To explore the clinical characters in patients of dilated cardiomyopathy （DCM） combined with pulmonary hypertension （PH）. Methods Ninty eight cases of DCM confirmed by eehocardiography were divided into control group（n=43 ）and PH group（n=55）. The clinical and biochemical features and the find- ings by echocardiography were compared between the two groups. Results There were no remarkable differences in the general clinical data in both groups. While the left ventricle end-diastolic dimension [ （72.36±11.14）mm vs （66.82±10.54）mm], dimension of the left atrium [（51.76±9.25）mm vs （43.13±8.93）mm], right ventricular [（27.93±6.85）mm vs （21.47±5.09）nun] and the serum level of brain natriuretic peptide （BNP）[（1254.73± 569.36）ng/m1 vs （573.26±257.14）ng/ml] were significantly higher while ejective fraction [ （28.51±9.36）% vs （35.73±10.51）% ] was significantly lower in PH group than those in control group, P〈0.05 respecttively. Conclu- sion DCM patients combined with pulmonary hypertension is linked with worse clinical features than without pul- monary hypertension.