食品对抗感染药物疗效的影响

Effect of Food on the Efficacy of Anti-infective Drug

目的:研究分析食品对抗感染药物疗效的影响。方法:通过广泛收集相关食物影响抗感染药物疗效的资料,来分析食物对抗感染药物疗效影响的作用机制,并对这些受影响的抗感染药物进行整理。结果:对于一些特定的抗感染药物来说,某些食物会极大影响其被人体吸收的效果,并会改变药物的BA(生物利用度)以及t1/2、AUC、Tmax、和Cmax等相关的动力学参数,甚至还会引起病人的不良反应。通过对这类受影响的抗感染药物进行分析整理,以作为临床用药的参考;再通过合理用药,使药物的疗效可以得到充分的发挥,从而促进病人的早日康复。结论:在使用临床抗感染药物的时候,要注意用药时间、合理安排饮食时间、调整好饮食结构等,这样才能保证抗感染药物疗效的充分发挥,并有效减少病人服药之后出现不良反应的情况。

[Objective] To study the effect of food on the efficacy of anti-infective drug. ｜Methodl By collecting relevant data, the mechanism of food to affect the efficacy of anti-infective drug was studied, and the affected drugs were introduced. LResult] For some specific anti-infective drugs, certain foods would greatly influence the effect of the absorption by the body, and change the relevant kinetic param- eters drug like BA （bioavailability）, AUC, t1/2, Tmax ,Cmax and etc. , and even cause the patient＇s adverse reactions. Based on analysis of affected anti-infective drugs, as the reference of clinical drugs, and then through the rational use of drugs, the drug effect could be brought into full play, so as to promote the patient＇s recovery. LConclusionJ In the clinical use of anti-infective drugs, doctors should pay attention to the reasonable arrangement of time of medication, diet time and diet structure, so as to ensure the efficacy of anti-infective drug, and effectively reduce medication adverse reactions.