输送蛋白多肽类药物的载体材料的研究进展

Progress of Carrier Materials in Drug Delivery System for Proteins

具有优良性能的药物载体材料的研发对于开发蛋白药物的给药新剂型具有重要意义。本文综述了近年来蛋白类药物递送体系中所使用的几类载体材料,主要介绍了人工合成及天然的可生物降解材料、不可降解的高分子材料和PEG嵌段共聚物材料等,以及相关的药物负载技术。

The drug carriers with excellent properties produce significant influences on the development of new administrations of protein drugs. The carrier materials used in the drug delivery systems for protein drugs are reviewed in this paper. Here, artificial and natural biodegradable materials, non-degradable polymer carrier materials, block copolymer materials containing PEG segments and related drug loading technologies are introduced.