摘要
PET/CT显像作为一种诊断肿瘤、评价疗效和预后的有力工具得到了快速的发展。氨基酸类正电子药物被临床证明是可以弥补当前18F-FDG PET/CT不足的重要药物,不像18F-FDG,氨基酸类分子探针在正常脑组织中的摄取很低,在良性的病变如炎症、水肿、坏死和纤维化的组织几乎不摄取,可以提高PET/CT显像的特异性,其合成标记的研发日益得到重视。本文重点介绍了当前利用短半衰期正电子核素18F和11C标记合成正电子类氨基酸的方法学和初步应用研究的最新进展。
Background： Positron emission tomography （PET） is in rapidly developing as a powerful imaging technique for diagnosis, efficacy evaluation and prognosis of tumor. In contrast to ^18F-FDG, the amino acid tracers were helpful additional tools for differentiating tumor tissue and inflammation, edematous, necrotic and fibrotic tissue because of their low uptake in those tissues, so that amino acid tracers appear to be more specific than the widely used ^18F-FDG As a result, a number of attempts have been undertaken for radio-synthesis of amino acid with short half-life nuclide ^18F and ^11C. Purpose： The aim is to review and discuss the present knowledge on synthesis methods and preliminary clinic application of labeling amino acid. Methods： The advances on the synthesis methods and preliminary clinic application of labeling amino acid in recent years were introduced and discussed. Results： In recent years, many new ^18F or ^11-labeled amino acids have been developed and their preliminary clinic applications were studied. Conclusion： The review provides an overview of this class of radiolabeled amino acids and highlights the current synthesis status and the key preliminary clinic applications.
出处
《核技术》
CAS
CSCD
北大核心
2014年第8期23-29,共7页
Nuclear Techniques
基金
广东省科技计划项目(No.2013B)资助
