血脂康对不同体质类型冠心病患者血脂水平及血管内皮功能的影响

Influences of Xuezhikang Capsules on blood fat level and vascular endothelial function in CHD patients with different TCM constitutional types

目的明确血脂康降脂作用,探讨体质因素对血脂康疗效的影响。方法随机选择4种冠心病常见体质类型各50例冠心病患者为治疗组,另随机选择50例冠心病患者作为对照组,50名健康体检者作为健康对照组。对照组采用常规治疗;治疗组在常规治疗的基础上给予血脂康治疗12周,观察治疗前后内皮素(ET-1)、一氧化氮(NO)和血脂水平变化。结果血瘀质和痰湿质患者治疗组用药后各项血脂指标与同组用药前和对照组用药后相比都具有显著差异(P<0.05);气虚质患者治疗组的低密度脂蛋白胆固醇(LDL-C)指标与用药前和对照组用药后相比也具有显著差异(P<0.05);血瘀质和痰湿质治疗组用药后血管内皮功能指标与用药前、对照组用药后相比都具有显著差异(P<0.05);冠心病血瘀质和痰湿质治疗组的心绞痛改善疗效和心电图改善疗效优于气虚质和阳虚质组(P<0.05)。结论血脂康对血瘀质和痰湿质体质类型冠心病患者总体治疗效果和对血脂水平及血管内皮功能的改善效果优于气虚质和阳虚质冠心病患者。

Objective To definite the lipid-lowering effect of Xuezhikang Capsules, and discuss the influence of TCM constitutional factors on the curative effect of Xuezhikang Capsules. Methods The patients with coronary heart disease （CHD） and 4 constitutional types （ n = 50） were randomly selected as treatment group, 50 patients with CHD were selected as control group, and other 50 health volunteers were selected as health group. The control group was treated with routine therapy, and treatment group was additionally given Xuezhikang Capsules for 12 w. The changes of levels of endothelin-1 （ ET-1 ）, nitric oxide （NO） and blood fat were observed before and after treatment. Results All lipid indexes had significant difference in blood stasis constitution group and phlegm dampness constitution group after treatment compared with those before treatment and those in control group after treatment （ P 〈 0.05 ）. The level of LDL-C had significant difference in qi deficient constitution group after treatment compared with those before treatment and those in control group after treatment （ P 〈 0.05 ）. The indexes of vascular endothelial function had significant difference in blood stasis constitution group and phlegm dampness constitution group after treatment compared with those before treatment and those in control group after treatment （P 〈 0.05 ）. The curative effects on angina pectoral and electrocardiogram were better in blood stasis constitution group and phlegm dampness constitution group than those in qi deficient constitution group and yang deficient constitution group （P 〈 0.05 ）. Conclusion The overall curative effect and improving effects of Xuezhikang Capsules on blood fat and vascular endothelial function are better in CHD patients with blood stasis constitution or phlegm dampness constitution than those in CHD patients with qi deficient constitution or yang deficient constitution.