蒙药漏芦花中黄酮类化合物的研究

Study on flavanoids of Rhaponticum uniflorum

采用大孔树脂柱色谱法及制备高效液相色谱法等分离手段从漏芦花中分离得到10个化合物,通过理化性质及波谱分析并结合文献对照分别鉴定为5,7,3'-三羟基-6,4'-二甲氧基黄酮(1)、5,7,3'-三羟基-4'-甲氧基黄酮(2)、芹菜素(3)、木犀草素(4)、槲皮素(5)、木犀草素-7-O-α-D-葡萄糖苷(6)、槲皮素-3-O-α-D-鼠李糖苷(7)、芹菜素-7-O-α-D-葡萄糖苷(8)、芦丁(9)、芹菜素-7-O-α-D-葡萄糖醛酸苷(10)。除化合物5外,其余化合物均为首次从该植物中分离得到。

Ten compounds were isolated from the flavanoids of Rhapontf, um urdflorum by macroporous resin and prepara- tion HPLC. Their structures were identified by physicochemical properties, spectroscopic analysis and comparison with the data of literatures. These 10 compounds were S, 7,3 ＇-tfihydroxy -6,4 ＇-dimethoxy flavone （ 1 ）, 5,7,3 ＇-trihydroxy--4 ＇- methoxy flavone （2）, pelargidenon （3）, luteolin （4）, quercetin （ 5）, luteolin-7 - O-α-D-glucopyranoside （6）, quereetin-3 - O-α-D-rhamnoside （7）, apigenin-7-O-α-D-glucopyranoside （8）, Rutin （9）, apigenin -7-O-α-D-glucuronid （10）. In ad- dition to compound5 ,the rest were isolated from this plant for the first time.