绞股蓝皂苷对高尿酸血症大鼠血尿酸的影响

Effect of Gypenoside on Serum Uric Acid of Hyperuricemic Rats

高尿酸血症是近年来日益多发的代谢综合征。本研究探讨绞股蓝皂苷提取物对高尿酸血症大鼠血清尿酸的影响及作用方式。研究采用高尿酸血症大鼠动物模型,生化检测,代谢实验方法等,对摄入绞股蓝皂苷提取物的实验大鼠的血清尿酸水平,尿酸生成关键酶黄嘌呤氧化酶活性,24 h尿液酸碱度、尿酸浓度及尿酸排泄量等指标进行监测。结果发现,绞股蓝皂苷可以通过抑制尿酸生成,促进排泄,抑制机体的血尿酸水平升高,有益于改善高尿酸血症患者健康状况。

Hyperuricemia is an increasing risk of metabolic syndrome in recent years. This study explored the effect and mechanism of gypenoside on serum uric acid concentration in hyperuricemic rats. The secondary hypentricemia rat model induced by unreasonable dietary structure was made by intragastric administration of yeast and potassium oxonate. Indi- cators of hyperuricemic rats,including serum uric acid concentration, oxidase activity of xanthine in serum and uric acid excretion in 24 hours, were monitored. The results of biochemical detection showed that the＇concentration of serum uric acid in hyperuricemic rats of each gypenoside group were obviously lower than those in model group. In addition,the oxi- dase activity of xanthine in serum and uric acid excretion in 24 hours of gypenoside groups with different dosages had no significant differences. Hence,it was hypothesized that gypenoside played a role in inhibiting uric acid generation without inhibiting the activity of xanthine oxidase. On the other hand, there was no obvious difference in pH value of each group, while the concentration of serum uric acid in each gypenoside group were obviously higher than those in model group. Hence,it was＂ hypothesized that gypenoside promoted the dissolution of serum uric acid in the urine. Based on those experimental results,it was concluded that gypenoside was beneficial for improving health status in patients with hyperuricemia by reducing the body＇s serum uric acid concentration via inhibiting generation and promoting excretion.