致病性大肠埃希菌常见毒力因子分子生物学特征研究进展

Advances on Molecular Biological Characters of Virulent Factors from Pathogenic Escherichia coli

大肠埃希菌常见的毒力因子包括肠毒素、黏附素性菌毛、类志贺菌毒素及毒力岛等,这些毒力因子决定了大肠埃希菌的致病性。研究毒力因子能够了解大肠杆菌的致病机制,进而根据该菌的致病机制开发免疫制剂和靶向药物。为了阐明大肠杆菌的致病机制,更好地防控该病,文中对该菌的肠毒素、黏附素性菌毛、类志贺菌毒素及毒力岛等的分子生物学研究进展进行了综述。

Common virulent factors of Escheriehia coli include enterotoxin, adhesion pill, Shiga toxin and pathogenicity island, etc. These factors determine the virulence of pathogenic E. coli. To study virulent factors can help the understanding of the pathogenesis of E. eoli, and then develop preventive products and aimed drugs based on the characters of pathogenic bacteria. For declaring the pathogenesis of the pathogen to prevent and the control the disease, enterotoxin, adhesion pili, Shiga toxin and pathogenicity islands were reviewed in the paper.