联合检测尿NGAL、KIM-1对危重患儿急性肾损伤的临床意义

The Clinical Significances of Detecting Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Critically Ill Children with Acute Renal Injury

目的:探讨联合检测尿NGAL、KIM-1在判断重症患儿急性肾损伤(AKI)病情及预后中的作用。方法:以我院肾内科、PICU和健康体检儿童为观察对象,分为重症AKI组,重症非AKI组,CKD组和健康对照组,比较各组的血肌酐(sCr)和尿NGAL、尿KIM-1水平。结果:重症AKI组尿NGAL、KIM-1较重症非AKI组、CKD组、健康对照组明显升高(P<0.05),重症非AKI组、CKD组、健康对照组各组间差别无统计学意义(P>0.05)。尿KIM-1联合尿NGAL的峰值升高倍数和肾预后呈正相关,和CCr呈负相关关系。结论:尿NGAL和尿KIM-1水平与重症患儿AFI严重程度及肾预后有关。

Objective： To explore the predictive value of neutrophil gelatinase-associated lipocalin （NGAL）and kidney injury molecule-1 （KIM-1 ）in critically ill Children with AKI. Methods： Children from PICU, department of nephrology and health examination center were divided into critically ill chilgren with AKI group （AKI group）, critically ill children with non-AKI （non-AKI group）,CKD group,healthy control group （control group）. Serum creatinine（sCr） ,urine NGAL and urine KIM-1 were compared among the four groups. Results： The urine NGAL and urine KIM-1 increased significantly in AKI group than those in the other three groups （all P 〈 0.05）. There was no significant difference of urine NGAL and urine KIM-1 among non- AKI group, CKD group and control group （all P 〉 0.05）. The renal prognosis were positive correlated with the increased times of peak urine KIM-1 and urine NGAL, whlile CCr was negatively correlated. Conelusion：The levels of urine NGAL and urine KIM-1 may predict the severity of renal injury and renal prognosis.