ω-3鱼油脂肪乳对脑外伤后全身炎症反应综合征的影响

Effects of ω-3 Fish Oil Fat Emulsion on Patients with Systemic Inflammatory Response Syndrome after Brain Injury

目的:探讨ω-3鱼油脂肪乳对脑外伤合并全身炎症反应综合征(SIRS)患者体内血C反应蛋白(CRP)及体液免疫的影响。方法:将2011年6月-2013年12月收治的脑外伤合并SIRS患者96例随机分为对照组和实验组各48例,分别给予常规静脉营养和联合ω-3鱼油脂肪乳治疗,比较两组静脉营养前1d,后第7 d的肿瘤坏死因子-α(TNF-α)、CRP、白介素-6(IL-6)的浓度。结果:治疗后两组血TNF-α、CRP、IL-6等水平均较治疗前明显降低(P<0.05),但实验组第7 d时的观察指标均明显低于对照组(P<0.05)。结论:ω-3鱼油脂肪乳可降低脑外伤合并SIRS患者体内TNF-α、CRP、IL-6浓度,具有抗炎和改善免疫功能的作用。

Objective：To explore the effects of ω-3 fish oil fat emulsion on the C-reactive protein （CRP）and humoral immune function on patients with systemic inflammatory response syndrome （SIRS） after brain injury. Methods：96 patients with SIRS after brain injury were randomly divided into control group （n=48） and experiment group （n=48） from Jun 2011 to Dec 2013, and accepted routine total parenteral nutrition （TPN） and combined ω-3 fish oil fat emulsion respectively. C-reactive protein （CRP）, tumor necrosis factor-α （TNF-α） and interleukins-6 （IL-6） were tested before and after 7d underwent nutrition respectively. Results： The levels of CRP, TNF-α and IL-6 were significantly lower after nutrition treatment than before nutrition in the both groups, but there were significantly lower in experiment group than those in control group after 7 d nutrition treatment, all P 〈0.05. Conclusion： ω-3 fish oil fat emulsion can decrease significantly the level of TNF-α, CRP and IL-6 in patients with SIRS after brain injury, resulting in the reduction of inflammatory reaction and enhancement of humoral immune function.