别嘌醇致中毒性表皮坏死松解症的风险因素分析与措施

Risk Analysis and Measures of Toxic Epidermal Necrosis Caused by Allopurinol

通过对别嘌醇致中毒性表皮坏死松解症临床症状和发病机制分析,进一步探讨其导致中毒性表皮坏死松解症的各种风险因素(包括年龄、性别、肝肾功能不全、日剂量与疗程、药物相互作用、认识不足和特殊人群等),并提出控制其严重不良反应的措施,以期对临床安全使用别嘌醇、有效防范与控制其危害提供参考与借鉴。

By analyzing clinical symptoms and pathogenesis of toxic epidermal necrolysis induced by allopurinol, various risk factors of its toxic epidermal necrolysis were discussed including age, sex, liver and kidney dysfunction, daffy dose and duration of use, drug interactions, and special populations, et al. Measures to control serious adverse reactions were proposed. It hopes to provide references for clinical safe use of allopurinol, effective prevention and control of its harm.