联合孟鲁司特钠治疗小儿毛细支气管炎效果观察

Effect of Conventional Treatment Combined with Montelukast Sodium in Children with Bronchiolitis

目的观察联合孟鲁司特钠治疗小儿毛细支气管炎的临床效果。方法选择小儿毛细支气管炎88例随机分为观察组和对照组两组,每组44例。对照组采用常规治疗,观察组在常规治疗基础上给予孟鲁司特钠治疗,观察比较两组临床疗效,症状、体征消失或缓解时间及不良反应情况。结果观察组治疗总有效率高于对照组,肺部啰音、咳嗽消失时间及喘憋缓解时间短于对照组,两组比较差异均有统计学意义(P<0.05)。两组治疗期间均出现不同程度不良反应,不良反应发生率比较差异无统计学意义(P>0.05)。结论在常规治疗基础上给予孟鲁司特钠治疗小儿毛细支气管炎可明显提高临床疗效,缩短症状、体征消失或缓解时间。

Objective To observe the clinical effect of conventional treatment combined with Montelukast sodium in children with bronchiolitis. Methods A total of 88 children were randomly divided into observation group and control group （44 in each）. Children in the control group were given the conventional treatment, and then, children in the observation group were given administration of Montelukast sodium on the basis of conventional treatment. The clinical effect, symptoms and signs remission time and adverse reactions in the two groups were compared. Results The total effective rate in the ob-servation group was higher than that in the control group, the duration of clinical symptoms such as pulmonary rales, coughing and wheezing in observation group were significantly shorter than those in control group, and the differences were significant （P＆lt;0. 05）. Both groups represented adverse reactions in some degree, but the difference of adverse reaction occurrence rate in the two groups showed no significance （P＆gt;0. 05）. Conclusion Montelukast sodium in treatment of children bronchiolitis based on conventional method could improve the therapeutic effect and shorten symptoms and signs remission time.