TFPI-2对动脉粥样硬化斑块不稳定相关因素影响的研究进展

Research Progress on the Influence of TFPI-2 on the Instability Factors Related to Atherosclerotic Plaque

动脉粥样硬化斑块处内皮细胞及巨噬细胞的功能、血管平滑肌细胞(VSMC)增殖状况、基质金属蛋白酶(MMP)及凝血酶活性是动脉粥样硬化斑块不稳定的重要相关因素。组织因子途径抑制物2(TFPI-2)是组织因子的生理性拮抗物,可抑制组织因子启动的外源性凝血途径和血栓形成。组织因子途径抑制物是MMP等物质的内源性抑制物,影响VSMC的迁移和MMP表达,TFPI-2/MMP比例失衡对斑块纤维帽稳定性有重要影响,进而影响急性冠状动脉综合征的发生及预后。

Function of endothelial cells and macrophages, proliferation of vascular smooth muscle cells （ VSMC ）, activity of matrix metalloproteinases （MMPs） and thrombin are important factors related to the instability of atherosclerotic plaque. Tissue factor pathway inhibitor-2 （ TFPI-2 ） is a physiological antagonist of tissue factor by inhibiting tissue factor from triggering physiological antagonism pathway and thrombosis. TFPI-2 is also an endoge-nous inhibitor of MMPs by affecting VSMC＇s immigration and MMPs＇ expression. The disequilibrium of TFPI-2/ MMPs ratio has an important influence on the stability of plaque fibrous cap, thus affect the occurrence and prognosis of acute coronary syndrome.