摘要
凝血酶原片段1+2(F1+2)是凝血酶原酶复合物激活凝血酶原的过程中从凝血酶原上解离出的多肽片段。近年来研究显示,F1+2浓度升高与多种心血管危险因素相关。进一步研究表明F1+2与心血管疾病,如急性冠状动脉综合征、心房颤动、静脉血栓形成、卒中等有密切的联系,并且对血栓形成疾病的诊断、预后的评估有一定潜在价值。
Prothrombin fragment 1 ＋ 2 （ F1 ＋ 2） comes from cleavage of prothrombin. Elevated F1 ＋ 2 has been found in relation to the presence of cardiovascular disease risk factors. Increased F1 ＋ 2 levels have been reported in acute coronary syndromes, atrial fibrillation, venous thromboembolism, and stroke. Further more, elevated FI ＋ 2 shows potential diagnostic and prognostic value in thrombosis disease.
出处
《医学综述》
2014年第15期2711-2713,共3页
Medical Recapitulate
关键词
心血管疾病
凝血因子
凝血酶原片段1+2
Cardiovascular disease
Coagulation factor
Prothrombin fragmeutl ＋ 2
