2型糖尿病伴高尿酸血症的临床特点

Clinical Characteristics of Type 2 Diabetes Mellitus Patients with Hyperuricemia

目的分析并评价2型糖尿病伴高尿酸血症的临床特点。方法将汤阴县人民医院门诊及住院部2012年1月至2013年3月收治的440例2型糖尿病患者根据血尿酸水平分为糖尿病伴高尿酸血症组(102例)与糖尿病正常血尿酸水平组(338例),比较两组患者的空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、三酰甘油(TG)、胆固醇(CHO)、肌酐(Cr)水平,以及体质量指数和并发症发生情况。结果糖尿病伴高尿酸血症组患者TG、Cr、FINS水平以及BMI显著高于糖尿病正常血尿酸组,HDL显著低于糖尿病正常血尿酸组(P<0.05);HbA1c、FPG、CHO及LDL水平与糖尿病正常血尿酸组比较无统计学意义(P>0.05)。糖尿病伴高尿酸血症组患者高血压、冠状动脉硬化性心脏病、脑卒中以及糖尿病视网膜病变的发生情况显著高于糖尿病正常血尿酸组(P<0.01)。结论2型糖尿病患者不但要调控体质量、血糖、血脂、血压等,还应监测血尿酸水平,尽早采取相应的干预措施,延缓疾病进展。

Objective To analyze and evaluate the clinical characteristics of type 2 diabetes mellitus patients with hyperuficemia. Methods A total of 440 cases of type 2 diabetes mellitus patients admitted in Tangyin County People＇s Hospital from Jan. 2012 to Mar. 2013 were divided into two groups according to the blood uric acid level： diabetes with hyperuricemia group（ 102 cases）and diabetes with normal blood uric acid group（338 cases）. The indexes of fasting plasma glucose（ FPG）, fasting insulin （ FINS）, glycosylated hemoglobin （ HbAlc ）, high density lipoprotein（HDL） ,low density lipoprotein （ LDL）, triacylglycerol （ TG）, cholesterin （ CHO ）, creatinine （ Cr）, as well as the body mass index（BMI） and the complication occurrence of the two groups were compared. Results The TG,Cr,FINS levels and BMI of the diabetes with hyperuricemia group were higher than that of the diabetes with normal blood uric acid group,HDL level of the diabetes with hyperuricemia group was lower than that of the diabetes with normal blood uric acid group（ P 〈 0.05 ）. There were no significant difference of HbAt~, FPG, CHO and LDL levels between the two groups （ P 〉 0.05 ）. The incidence rates of hypertension, coronary heart disease, stroke and diabetic retinopathy of the diabetes with hyperuricemia group were significantly higher than that of the diabetes with normal blood uric acid group （ P 〈 0.01 ）. Conclusion The type 2 diabetes patients should not only control the body weight, blood glucose, blood lipid, blood pressure and other indicators, but also have to monitor the blood uric acid level, and take neceessary intervention measures as soon as possible, in order to postpone the progression of the disease.