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吉西他滨每周方案或联合奥沙利铂治疗老年肺癌

Study on Gemcitabine Weekly Therapy and Gemcitabine Combined with Oxaliplatin Therapy in the Treatment for Senile Lung Cancer
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摘要 目的 探讨吉西他滨单药或联合奥沙利铂每周方案治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效及安全性。方法 选择2009年10月至2012年10月在佛冈县人民医院就诊的48例老年NSCLC患者作为研究对象,按数字表随机法将患者分为吉西他滨单药组及吉西他滨联合奥沙利铂组,吉西他滨单药组给予吉西他滨单药每周方案,吉西他滨联合奥沙利铂组在吉西他滨单药组的基础上联合奥沙利铂治疗。治疗完成后对患者的生活质量、临床客观有效率(ORR)、疾病控制率(DCR)及毒性反应进行评价。结果 两组患者治疗完成情况相当(χ2=0.181,P=0.671)。吉西他滨单药组患者生活质量好转情况与吉西他滨联合奥沙利铂组比较,差异有统计学意义(Z=2.272,P=0.023)。两组患者的客观有效率分别为17.4%、50.0%,疾病控制率为56.5%、83.3%,两组比较差异均有统计学意义(χ2=4.372,P=0.037;χ2=4.037,P=0.045)。两组患者的毒性反应相当,多为Ⅰ-Ⅱ度,比较差异无统计学意义(P〉0.05)。结论 吉西他滨联合奥沙利铂每周方案治疗老年晚期NSCLC的疗效优于吉西他滨单药,其近期疗效及安全性较好。 Objective To compare the curative effect and safety of gemcitabine weekly therapy and gemcitabine combined with oxaliplatin therapy in the treatment of non-small cell lung cancer ( NSCLC ) among elderly patients. Methods A total of 48 elderly patients with NSCLC treated in Fogang County people's Hospital from Oct. 2009 to Oct. 2012 were selected and divided into gemcitabine group and gemcitabine combined with oxaliplatin group according to random number table. Patients in gemcitabine group were only treated with gemcitabine weekly therapy,while patients in gemcitabine combined with oxaliplatin group were treated with gemcitabine and oxaliplatin. After treatment, the life quality, objective clinical response rate ( ORR), disease control rate (DCR) and toxicity reactions of the two groups were evaluated. Results The completion status of treatment was equal between gemcitabine group and gemcitabine combined with oxaliplatin group( χ2 =0. 181 ,P =0. 671 ). The life quality of the two groups had significant statistical difference( Z = 2. 272,P = 0. 023). ORR and DCR of gemcitabine group were 17.4% and 56.5% respectively,while that of gemcitabine combined with oxaliplatin group were 50.0% and 83.3%, the difference of ORR and DCR between the two groups was statistically significant ( χ2 = 4.372,P = 0. 037 ; χ2 = 4.037, P = 0.045 ). Toxicity reac- tions of the two groups were similar and most of the toxicity reactions belonged to grade Ito II,and there was no significant statistical difference(P 〉 0.05). Conclusion Gemcitabine combined with oxaliplatin is superior to single gemcitabine therapy in the treatment of advanced senile NSCLC and has better recent curative effect and safety.
出处 《医学综述》 2014年第15期2865-2867,共3页 Medical Recapitulate
关键词 吉西他滨 奥沙利铂 老年 晚期非小细胞肺癌 Gemcitabine Oxaliplatin Elderly Non-small cell lung cancer at late stage
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  • 1尹月,邱新野,刘泽源.老年非小细胞肺癌患者化疗药物治疗进展[J].中国药物应用与监测,2012,9(3):169-172. 被引量:14
  • 2Sperandi F, Melotti B, Martoni AA. Gemcitabine ( GEM ) ( day 1-8 ) plus carboplatin (CBDCA) ( day2 ) for the treatment of advanced non-small cell lung cancer(aNSCLC) in elderly or poor performance status(PS) patients(pts) [J]. J Clin Oncol,2007,2.5(18) :18116.
  • 3周际昌.实用肿瘤内科学[M].2版.北京:人民卫生出版社,2005:92-94.
  • 4Eiseahauer EA, Therasse P, Bogaerts J, et al. New response evalua- tion criteria in solid tumoum: revised RECIST guideline( version 1.1 ) [J]. Eur J Caner,2009,45(2) :228-247.
  • 5孙燕.临床肿瘤内科手册[M].5版.北京:人民卫生出版社,2008:597.
  • 6Davidoff A J, Tang M, Seal B, et al. Chemotherapy and survival ben- efit in elderly patients with advanced non-small-cell lung cancer [J]. J Clin 0ncol,2010,28(13) :2191-2197.
  • 7何海浪,王谦,赵阳,刘会平,曹振东,周贤梅.参附注射液联合含铂一线化疗方案治疗非小细胞肺癌的Meta分析[J].中国实验方剂学杂志,2013,19(14):331-339. 被引量:29
  • 8Azzoli CG, Temin S, Aliff T, et al. 2011 focused update of 2009 American society of clinical oncology clinical practice guideline update on chemotherapy for stage 1V non-small-cell lung cancer [J]. J Clin Oncol,2011,29(28) :3825-3831.
  • 9Quoix EA, Oster J, Westeel V, et al. Weekly paclitaxel combined with monthly carboplatin wersus single-agent therapy in patients age 70 to 89 : IFCT-O501 randomized phase II[ study in advanced non-small cell lung cancer (NSCLC) [ J ]. J Clin Oncol, 2010,28 (18):2.
  • 10马望,路太英,王留兴,王瑞林,樊青霞.多西他赛联合奥沙利铂一线治疗晚期非小细胞肺癌的临床观察[J].中华临床医师杂志(电子版),2010,4(6):860-861. 被引量:8

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