益肾化瘀汤联合中药外敷治疗子宫内膜异位症50例临床观察

Observation of Yishen Huayu decoction combined with external application of Chinese medicine on endometriosis

目的观察益肾化瘀汤联合中药外敷治疗子宫内膜异位症(EMS)的临床疗效。方法将150例EMS患者随机分为3组,治疗组50例予益肾化瘀汤联合中药外敷治疗,对照1组50例予益肾化瘀汤治疗,对照2组50例予孕三烯酮胶囊治疗。3组均治疗3个月,观察病情程度、血清糖类抗原125(CA125)、子宫体积变化,比较3组疗效,统计停药12个月后复发率。结果 3组治疗后病情程度均较本组治疗前改善(P<0.05)。3组停药12个月后血清CA125均较本组治疗前下降(P<0.05);子宫体积均较本组治疗前减小(P<0.05)。治疗组总有效率高于对照组(P<0.05),治疗组疗效优于对照组。治疗组复发率低于对照组(P<0.05),治疗组远期疗效优于对照组。结论益肾化瘀汤联合中药外敷治疗EMS,疗效显著,缓解经期疼痛,改善盆腔体征,延缓病情向重度发展,减少复发率,值得临床推广应用。

Objective To observe the effect of Yishen Huayu decoction combined with external application of Chinese medicine on endometriosis （EMS）. Methods 150 EMS patients were randomly divided into three groups. 50 cases in treatment group received Yishen Huayu decoction combined with external application of Chinese medicine. 50 cases in control group one received Yishen Huayu decoction. 50 cases in control group two received gestrinone capsules. The course was three months in three groups. After a course severity of illness, carbohydrate an- tigen 125 （CA125）, uterine volume was observed, effect and withdrawal relapse rate after 12 months were compared within the three groups. Results Severity of illness after treatment was improved as compared with that before treat- ment in three groups （ P 〈0.05 ）. The levels of CA125 in 12 months after stopping were decreased in comparison with those before treatment in three months （ P 〈 0.05 ）. Uterine volume in 12 months after stopping was decreased （ P 〈 0.05 ）. The total effective rate in treatment group was higher than that in control group （ P 〈 0.05 ）. Treatment group recurrence rate is lower than the control group （ P 〈 0.05 ）, long curative effect in treatment group was superior to control group. Conclusion Curative effect of Yishen Huayu decoction combined with external applica- tion of Chinese medicine on endometriosis is distinct, ease menstrual pain, improve pelvic signs, defer illness to se- vere development, and reduce the recurrence rate, worthy of clinical popularization and application